Tra i perversi effetti collaterali della campagna vaccinale di massa,
la generazione selettiva di varianti del virus, più contagiose ed aggressive
che prolungheranno restrizioni, sofferenza e morte.
Le conoscenze scientifiche che abbiamo lo affermano senza ombra di dubbio.
Sono onorato di ospitare nella rubrica Bersaglio Mobile il contributo di un docente di Fisica che ha sviluppato una dettagliata e documentata ricerca sulle correlazioni tra vaccini e varianti Covid-19
di Francesco Cappello
Fonte originale: articolo del 13 luglio 2021 dal blog Seminare Domande
L’immagine di copertina è tratta da https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953441/
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.
Keywords: COVID-19, SARS-CoV-2, spike, variants, RBD, neutralizing antibodies, escape, mRNA vaccines